Preimplantation Genetic Testing (PGT)

Common Questions

Question 1

What is Preimplantation Genetic Testing (PGT)?

PGT is a technique used to analyze embryos for genetic abnormalities before transferring them to the uterus during IVF. Dr. Karunakar Marikinti uses PGT to help ensure the healthiest embryos are selected for transfer, increasing the chances of a successful pregnancy.

Question 2

Who should consider PGT during their IVF treatment?

PGT is recommended for couples with a history of genetic disorders, recurrent miscarriages, or previous IVF failures. Dr. Karunakar Marikinti advises patients on whether PGT is appropriate based on their medical history and specific circumstances.

Question 3

What are the different types of PGT?

There are three main types: PGT-A (for aneuploidy), PGT-M (for monogenic/single gene defects), and PGT-SR (for structural rearrangements). Dr. Karunakar Marikinti provides guidance on the most suitable type of PGT based on individual genetic concerns.

Question 4

How is PGT performed?

After the eggs are fertilized and embryos develop, a few cells are biopsied from each embryo and analyzed for genetic abnormalities. Dr. Karunakar Marikinti ensures this process is done with precision to maintain the integrity of the embryos.

Question 5

What are the benefits of PGT?

PGT helps reduce the risk of transferring embryos with genetic abnormalities, thereby increasing the chances of a healthy pregnancy and reducing the likelihood of miscarriages. Dr. Karunakar Marikinti leverages PGT to optimize pregnancy outcomes for his patients

Question 6

Are there any risks associated with PGT?

While PGT is generally safe, there are minor risks associated with the embryo biopsy procedure. Dr. Karunakar Marikinti ensures that the procedure is performed by skilled professionals to minimize any potential risks.

Question 7

How long does it take to get PGT results?

PGT results typically take about one to two weeks, depending on the complexity of the tests. Dr. Karunakar Marikinti provides clear timelines and keeps patients informed throughout the testing process.

Question 8

What happens if an embryo is found to have genetic abnormalities?

Embryos with genetic abnormalities are usually not transferred to reduce the risk of genetic disorders in the baby. Dr. Karunakar Marikinti counsels patients on their options and next steps if abnormal embryos are identified.

Preimplantation Genetic Testing (PGT)

Preimplantation Genetic Testing (PGT) is an advanced reproductive technology that allows for the screening of embryos for genetic abnormalities before implantation during an IVF cycle. This procedure helps identify embryos with chromosomal abnormalities or genetic disorders, increasing the likelihood of a successful pregnancy. Here’s what you need to know about PGT:

1. Genetic Screening

PGT involves the screening of embryos to identify genetic abnormalities or chromosomal irregularities. This screening can be categorized into two main types: PGT-A (formerly known as PGS), which screens for chromosomal abnormalities, and PGT-M (formerly known as PGD), which screens for specific genetic disorders.

2. PGT-A (Aneuploidy Screening)

PGT-A is used to assess the chromosomal status of embryos, identifying abnormalities such as aneuploidy (an abnormal number of chromosomes). This screening is particularly beneficial for individuals with a history of recurrent miscarriages or failed IVF cycles due to chromosomal abnormalities.

3. PGT-M (Genetic Disease Screening)

PGT-M is employed to screen embryos for specific genetic diseases or disorders known to be present in the family history of the intended parents. This screening helps prevent the transmission of genetic conditions to future generations, offering peace of mind and reducing the risk of inherited diseases.

4. Procedure

The PGT procedure typically occurs during the early stages of embryo development, usually on day five or six following fertilization. A few cells are removed from each embryo, and the genetic material is analyzed using advanced techniques such as Next-Generation Sequencing (NGS) or Polymerase Chain Reaction (PCR).

5. Selection of Healthy Embryos

Following genetic screening, embryos determined to be chromosomally normal or free from specific genetic disorders are selected for transfer into the uterus during an IVF cycle. This selection process increases the likelihood of a successful pregnancy and reduces the risk of miscarriage or genetic conditions in offspring.

6. Benefits of PGT
  • Increased chances of a successful pregnancy: PGT helps identify healthy embryos, improving the likelihood of implantation and pregnancy.
  • Reduced risk of genetic disorders: Screening embryos for genetic abnormalities decreases the risk of passing on hereditary diseases to offspring.
  • Peace of mind: PGT provides reassurance to intended parents by ensuring the health and genetic integrity of embryos before transfer.

Why Choose Dr. Karunakar for PGT?

Dr. Karunakar Marikinti is a trusted expert in reproductive medicine, offering state-of-the-art PGT services with compassion and expertise. With a commitment to personalized care and cutting-edge technology, Dr. Karunakar is dedicated to helping you build your family with confidence and peace of mind.