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How does the connection between the embryo and the womb occur?
The connection begins when a fertilized egg implants into the uterine lining, initiating the development of the placenta. Dr. Karunakar Marikinti ensures this process is smooth and monitors early pregnancy to address any potential issues.
What factors affect embryo implantation?
Factors such as uterine health, hormone levels, and immune responses can impact implantation. Dr. Karunakar Marikinti utilizes advanced diagnostic techniques to identify and manage these factors, improving implantation success rates.
What is the role of the uterine lining in pregnancy?
The uterine lining, or endometrium, provides a nourishing environment for the embryo to implant and grow. Dr. Karunakar Marikinti helps patients optimize their endometrial health to support successful pregnancies.
Can an abnormal uterine environment lead to pregnancy loss?
Yes, conditions like thin endometrium, fibroids, or scar tissue can interfere with embryo implantation and growth, potentially leading to miscarriage. Dr. Karunakar Marikinti specializes in treating these conditions to promote a healthy uterine environment.
How does the placenta develop and function?
The placenta develops from the embryo and attaches to the uterine wall, providing oxygen and nutrients to the baby. Dr. Karunakar Marikinti monitors placental health throughout pregnancy to ensure optimal fetal development.
What are the signs of a successful embryo implantation?
Signs include a positive pregnancy test, rising hormone levels, and early pregnancy symptoms. Dr. Karunakar Marikinti offers early pregnancy monitoring to confirm successful implantation and address any concerns.
How can immune issues affect the connection between the embryo and the womb?
Immune system imbalances can cause the body to reject the embryo. Dr. Karunakar Marikinti uses specialized testing to identify immune-related issues and provides treatments to support embryo acceptance and growth.
Hysteroscopy is a simple and safe procedure that helps prevent miscarriage and implantation failures by allowing doctors to directly visualize and treat abnormalities within the uterus.
Ensuring the uterus is ready to receive and nurture an embryo is crucial for a successful pregnancy. Comprehensive tests are available to check if the female body is well-prepared to accept an embryo without rejection.
Carried out at Rosalind Franklin University Clinical Immunology Laboratory in Chicago
Systemic Inflammation:
Autoantibody-Inflammation:
Allo-immune Dysfunction:
Comprehensive Tests to check if Female Body is well Prepared to receive, nurture & not reject embryo(baby)
ADVANCED TEST Carried out at World’s most reputed ROSALIND FRANKLIN UNIVERSITY CLINICAL IMMUNOLOGY laboratory-Chicago Tests
Uterine NK cells (uNK) represent up to 70 % of the cells in endometrium during the implantation phase and secrete several cytokines (IL-12, IL-15, Fn-14, IL-18, LIF, TWEAK) modulating the uterine environment. An excessive number of uNK cells and the imbalance between IL-12/Fn-14 and IL-18/TWEAK have been recently shown as markers of immune profile dysregulation in women with RIF
SUCCESSFUL TREATMENTS POSSIBLE AFTER COMPRESHENSIVE TESTING OF IMPLANTATION FILAURE / MISCARRIAGE
ENDOMETRIAL IMMUNE PROFILE : DECIDUALISATION SCORE
MAJORITY (over 80%) OF IMPLANTATION FAILURE WOMEN HAD Immune Defect
one third of infertile could have displaced IMPLANTAITON WINDOW. 75% OF These ARE pre-receptive
Endometrial receptivity Array by NGS (on its own or part of Endotrio)
Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF
Class ISystemic Inflammation:
ALTERED systemic inflammatory immune responses demonstrated by Increased T helper 1 / T helper 2 balance [also called TH1:TH2 ratio abnormalities, or Cytokine ratio abnormalities] and/or increased natural killer cell numbers or activity.
Possible treatment includes:
Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF
Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF
Class III Autoantibody – Inflammation
Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF
Class IV Allo-immune Dysfunction
Women in this category have a lack of appropriate immune response to a pregnancy due to close genetic compatibility to their partner which can be identified through ‘HLADQ alpha matching’ of the couple.
TREATMENT:
Advanced Uterine Immune Testing for Miscarriage / Implantation Failure
Endometrial Immune Profile (EIP) & Decidualization Score
Dr. Karunakar Mirakanti specializes in diagnosing and treating issues related to abnormal connections between the baby and the womb. His approach includes:
If you are experiencing recurrent implantation failures or miscarriages, Dr. Karunakar is here to help. Schedule a consultation to explore advanced testing and personalized treatment options to improve your chances of a successful pregnancy.
Get personalized medical consultations directly from Dr. Karunakar.
Dr. Karunakar Marikinti is here to address your concerns and provide expert guidance through online consultations.
Twenty continuous years of experience at UK’s largest & most advanced Fertility Units and recently in UAE, in Assisted Reproductive Technology (ART)
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