Hysteroscopy(Telescoping Womb) helps to prevent Miscarriage and Implantation Failures and is Simple and Safe to Perform 

Uterine Receptivity

Comprehensive Teststo check if Female Body is well Prepared to receive, nurture & not reject embryo(baby) 

ADVANCED TEST

ADVANCED TESTCarried out at  World’s most reputed ROSALIND FRANKLIN UNIVERSITY CLINICAL IMMUNOLOGY laboratory-Chicago Tests 

 Uterine NK cells (uNK) represent up to 70 % of the cells in endometrium during the implantation phase and secrete several cytokines (IL-12, IL-15, Fn-14, IL-18, LIF, TWEAK) modulating the uterine environment. An excessive number of uNK cells and the imbalance between IL-12/Fn-14 and IL-18/TWEAK have been recently shown as markers of immune profile dysregulation in women with RIF
 

SUCCESSFUL TREATMENTS POSSIBLE AFTER COMPRESHENSIVE TESTING OF IMPLANTATION FILAURE / MISCARRIAGE 
 

ENDOMETRIAL IMMUNE PROFILE : DECIDUALISATION SCORE

MAJORITY (over 80%) OF IMPLANTATION FAILURE WOMEN HAD Immune Defect   

World’s largest Research on Immune Causes of Implantation Failures

•  28% had a local immune under-activation
•  45% had a local immune over-activation
•  10.5% had a mixed endometrial immune profile. 16.5% HAD NORMAL REPORTS.

Advanced Genetic Tests to avoid treatment failure: ERA

one third of infertile could have displaced IMPLANTAITON WINDOW. 75% OF These  ARE pre-receptive
Endometrial receptivity Array by NGS (on its own or part of Endotrio)
 

Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF
 

Class ISystemic Inflammation: 
 

ALTERED systemic inflammatory immune responses demonstrated by Increased T helper 1 / T helper 2 balance [also called TH1:TH2 ratio abnormalities, or Cytokine ratio abnormalities] and/or increased natural killer cell numbers or activity. 

Possible treatment includes:

• Steroids
• Low dose aspirin
• Heparin and Intralipid intravenous infusion
• Intravenous immunoglobulin (IVIg) or Humira may be used in women allergic to egg or soya.
  
   

Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF

Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF

Class III Autoantibody - Inflammation

• Women in this category have autoimmunity to fatty molecules, nuclear antigen, thyroid molecules or other tissues. Some of these patients have clinical manifestation of early mixed connective tissue disorder.
• Treatment may include : steroids, low dose aspirin and Heparin
• Patients with thyroid autoantibodies also require stabilization and close monitoring of thyroid function during treatment and pregnancy.
  
   

Four Subgroups of problems with the interaction of embryo(baby) and the female Uterus(womb)- any of them leading to RM/RIF
 

Class IV Allo-immune Dysfunction

Women in this category have a lack of appropriate immune response to a pregnancy due to close genetic compatibility to their partner which can be identified through ‘HLADQ alpha matching’ of the couple. 
 

TREATMENT:

• Steroids, 
• Low dose aspirin
• Heparin & Intralipid infusions. 
• Some authorities recommend Lymphocyte Immune Therapy (LIT) for this. This is a very controversial treatment
  
   

Advanced Uterine Immune Testing for Miscarriage / Implantation Failure

Endometrial Immune Profile (EIP) & Decidualization Score
 

https://doi.org/10.3389/fphys.2022.841437 

https://www.frontiersin.org/articles/10.3389/fimmu.2020.01032/full